Medmol  
Fibao Una perspectiva molecular en medicina

MEDMOL RESEARCH REPORTS (MMRR)



DOCUMENT

Analysis of the inducing factors involved in cardiomyocytic differentiation of stem cells using feature selection techniques, support vector machines and decision trees

Pablo Álvarez Aránega, Fernando Rodríguez-Serrano, Andrea M Trujillo, Octavio Caba Pérez, Ignacio Rojas, Jose Carlos Prados, Hector Pomares, Manuel Picón, Antonia Aránega, Alberto Prieto


DOI: 10.4428/MMRR.a.201005001


Document Type: Manuscript


Date: Received 21st May 2010 14:28 UTC; Posted 21st May 2010 14:43 UTC


Subjects: Bioinformatics, Stem cells


Tags:   stem cells   algorithms   support vector machine   decision trees   feature selection



6 votes
4 by authors
2 by users
1490 visits

Abstract:
Stem cells represent an invaluable source of cells for tissue regeneration, thanks to their ability to self-renewal and differentiate into functional cells of the tissues. The studies and results related to stem cell differentiation are diverse and sometimes contradictory due to the different stem cell types and the numerous variables involved in the differentiation process. In this paper a new methodology is proposed in order to select the relevant factors involved in stem cell differentiation into myocardial lineage and forecast its behaviour and response in the differentiation process. We have built a database from the results of experiments regarding cardiomyocytic differentiation of stem cells and using this database we have applied state-of-the-art classification and predictive techniques such as support vector machine and decision trees, as well as several feature selection techniques. The results obtained are very promising and demonstrate that with only a reduced subset of variables high prediction rates are possible.
Comments
0 comments
ADDITIONAL INFORMATION

License: This document is licensed to the public under the Creative Commons Attribution 3.0 License


 
MEDMOL RESEARCH REPORTS
User logged in:
Email:
Password:
Forgot your password?